Article
A multi-center study of ACE and the risk of late-onset Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2011
Belbin Olivia, Brown Kristelle, Shi Hui, Medway Christopher, Abraham Richard, Passmore Peter, Mann David, Smith A David, Holmes Clive, McGuinness Bernadette, Craig David, Warden Donald, Heun Reinhard, Kölsch Heike, Love Seth, Kalsheker Noor, Williams Julie, Owen Michael J, Carrasquillo Minerva, Younkin Steven, Morgan Kevin, Kehoe Patrick G
Abstract excerpt
A key pathological feature of late-onset Alzheimer's disease (LOAD) is the abnormal extracellular accumulation of the amyloid-β (Aβ) peptide. Thus, altered Aβ degradation could be a major contributor to the development of LOAD. Variants in the gene encoding the Aβ-degrading enzyme, angiotensin-1 converting enzyme (ACE) therefore represent plausible candidates for association with LOAD pathology and risk....
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