Article

Carriers of heterozygous loss-of-function ACE mutations are at risk for Alzheimer’s disease

2023-03-06

Abstract excerpt

Amyloid Aβ42 (constituents of the protein aggregates in the brains of patients with Alzheimer’s disease (AD) cleaved by ACE, and thus, a decrease in tissue ACE activity (constitutive or ACE inhibitor-induced) could be risk factor for AD. We hypothesized that subjects with heterozygous Loss-of-Function (LoF) ACE mutations are at risk for Alzheimer’s disease. Existing SNP databases were analyzed for LoF ACE mutation...

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Literature Corpus work: 356587f7-46c4-516d-bdda-7e7b90a1697e
DOI: 10.21203/rs.3.rs-2570701/v1

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