Article
A cladistic model of ACE sequence variation with implications for myocardial infarction, Alzheimer disease and obesity.
Human molecular genetics - 1 Nov 2004
Katzov Hagit, Bennet Anna M, Kehoe Patrick, Wiman Björn, Gatz Margaret, Blennow Kaj, Lenhard Boris, Pedersen Nancy L, de Faire Ulf, Prince Jonathan A
Abstract excerpt
Sequence variation in ACE, which encodes angiotensin I converting enzyme, contributes to a large proportion of variability in plasma ACE levels, but the extent to which this impacts upon human disease is unresolved. Most efforts to associate ACE with other heritable traits have involved a single Alu insertion/deletion polymorphism, despite the probable existence of other functional sequence variants with effects...
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