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Article

Effect of ACE mutations on blood ACE phenotype parameters.

PloS one - 1 Jan 2024

Kryukova Olga V, Korostin Dmitry O, Belova Vera A, Cheranev Valery V, Repinskaia Zhanna A, Uporov Igor V, Dudek Steven M, Kost Olga A, Rebrikov Denis V, Danilov Sergei M

Abstract excerpt

BACKGROUND: Analysis of existing mutations of Angiotensin-I-Converting Enzyme (ACE) led us to hypothesize that the carriers of damaging ACE mutations (accompanied by low ACE levels) could be at risk for the development of late-onset Alzheimer's disease (AD). METHODOLOGY/PRINCIPAL FINDINGS: We quantified blood ACE levels in EDTA-containing plasma from 15 patients with 11 different heterozygous ACE mutations and...

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Identifiers

PMID: 39378208
DOI: 10.1371/journal.pone.0308289
PMCID: PMC11460682

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