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Article

Alzheimer's disease-linked ACE variants increase ACE1 catalytic activity and production of angiotensin II.

The Journal of biological chemistry - 1 Mar 2026

Salvo Miranda A, Cuddy Leah K, Prokopenko Dmitry, Watkins Elyse, Tanzi Rudolph E, Vassar Robert

Abstract excerpt

Angiotensin-converting enzyme (ACE) is a validated risk locus for developing late-onset Alzheimer's disease (AD). Although ACE1 expression and enzyme activity correlate with AD diagnosis, the mechanism by which this occurs is unclear. As a cell membrane-bound and shed peptidase, ACE1 is most commonly known to produce angiotensin II (Ang II), which has been linked to AD pathogenesis but also has been shown to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41570992
DOI: 10.1016/j.jbc.2026.111171
PMCID: PMC12914408

Genes

ACE

Variants

rs3730043
rs4980
rs3730043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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