Article

Urinary Clusterin is a biomarker of renal epithelial senescence and predicts human kidney disease progression

2024-03-15

Abstract excerpt

Cellular senescence drives organ fibrosis and ageing, and accumulating evidence supports the ability of senescence-depleting drugs to improve outcomes in experimental models of disease. The lack of non-invasive biomarkers represents a major obstacle to the design of human trials of candidate senolytics. On samples from 51 patients with chronic kidney disease (CKD), we performed liquid chromatography mass spectrome...

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Literature Corpus work: 53d9f464-ae88-573a-93df-640312f86e60
DOI: 10.1101/2024.03.14.24303997

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