Article

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arrays

2024-01-20

Abstract excerpt

<h4>ABSTRACT</h4> Gene silencing without gene editing holds great potential for the development of safe therapeutic applications. Here, we describe a novel strategy to concomitantly repress multiple genes using zinc finger proteins fused to Krüppel-Associated Box repression domains (ZF-Rs). This was achieved via the optimization of a lentiviral system tailored for the delivery of ZF-Rs in hematopoietic cells. We...

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Literature Corpus work: 836c292f-b204-52ea-b83e-3d8458ec0361
DOI: 10.1101/2024.01.17.576049

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