Article

TRIM24 preserves cardiomyocyte immune quiescence by repressing interferon/STAT signaling

2025-11-13

Abstract excerpt

Innate immune activation in cardiomyocytes is a key driver of inflammatory heart disease and heart failure progression, yet the mechanisms by which cardiomyocytes maintain transcriptional immune quiescence remain poorly understood. TRIM24, a multidomain chromatin reader implicated in cancer and inflammation, has not been previously studied in the heart. Here, we investigated whether TRIM24 regulates interferon/STA...

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Literature Corpus work: 53912523-c3b9-5456-9d74-6c05fdfd2199
DOI: 10.1101/2025.11.13.688187

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