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Article

TRIM28 facilitates type I interferon activation by targeting TBK1

29 Feb 2024

Abstract excerpt

Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication. Activation of type I interferon is regulated by the IRF3 transcription factor, which undergoes phosphorylation-dependent activation by the upstream kinase, TBK1, during viral infection. However, the mechanisms by which TBK1...

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PMID: 38495890
DOI: 10.3389/fimmu.2024.1279920

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