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Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in <i>LMNA</i> -related dilated cardiomyopathy that are reversed by LINC complex disruption

2024-06-13

Abstract excerpt

Mutations in the LMNA gene, which encodes the nuclear envelope (NE) proteins lamins A and C, cause dilated cardiomyopathy ( LMNA -DCM) and other diseases. The pathogenic mechanisms for LMNA -DCM remain poorly understood, limiting current treatment options and leading to high mortality amongst patients. We developed a mouse model with inducible, cardiomyocyte-specific Lmna deletion (cKO) and performed comprehen...

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Literature Corpus work
ce2cfab1-5021-5a60-a9fc-11190ac2f06e
DOI
10.1101/2024.06.11.598511
Open publication

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Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in <i>LMNA</i> -related dilated cardiomyopathy that are reversed by LINC complex disruptionDOI 10.1101/2024.06.11.598511
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