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Article

Clinicopathological characteristics of patients with inoperable non-small cell lung cancer harboring circulating NRF2 pathway mutations.

The Journal of pathology - 1 Jun 2026

Härkönen Jouni, Tiainen Satu, Kujala Jouni, Muhonen Linnea, Mohanasundaram Ponnuswamy, Tikkanen Tuomas, Pöhner Ina, Patinen Tommi, Adinolfi Simone, Väyrynen Juha P, Auvinen Päivi, Mannermaa Arto, Pölönen Petri, Rauramaa Tuomas, Levonen Anna-Liisa

Abstract excerpt

Lung cancer is the leading cause of global cancer-related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2-related factor 2 (NRF2) is a redox-regulated transcription factor frequently dysregulated in non-small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy. In this study, we analyzed circulating cell-free tumor DNA from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41771797
DOI: 10.1002/path.70043
PMCID: PMC13140114

Genes

AKR1B10
AKR1C1
CUL3
KEAP1
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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