KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC.

doi:10.1016/j.jtho.2023.07.016

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Article

KEAP1/NFE2L2 Pathway Signature Outperforms KEAP1/NFE2L2 Mutation Status and Reveals Alternative Pathway-Activating Mutations in NSCLC.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Nov 2023

Arolt Christoph, Dugan Margaret, Wild Robert, Richartz Vanessa, Holz Barbara, Scheel Andreas H, Brägelmann Johannes, Wagener-Ryczek Svenja, Merkelbach-Bruse Sabine, Wolf Juergen, Buettner Reinhard, Catanzariti Luigi, Scheffler Matthias, Hillmer Axel M

Abstract excerpt

INTRODUCTION: Activation of the antioxidant KEAP1/NFE2L2 (NRF2) pathway leads to increased glutamine dependence and an aggressive phenotype in NSCLC. Because this pathway has been explored as a clinical target, we developed a transcriptomic signature for identifying KEAP1/NFE2L2-activated tumors. METHODS: A total of 971 NSCLC samples were used to train an expression signature (K1N2-score) to predict KEAP1/NFE2L2...

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PMID: 37473958
DOI: 10.1016/j.jtho.2023.07.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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