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NRF2 Participates in the Suppressive Tumor Immune Microenvironment of KRAS/KEAP1 Co-Mutant Non-Small Cell Lung Cancer by Inhibiting the STING Pathway

2022-01-03

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<title>Abstract</title> <p><bold>Background:</bold> KRAS/KEAP1 (KK) co-mutant lung adenocarcinoma (LUAD) exhibited poor response to immune checkpoint inhibitors (ICI) via shaping a suppressive tumor immune microenvironment, the mechanism remains to be elucidated. <bold>Methods:</bold> The mRNA and protein expression of target molecules were analyzed by qRT-PCR and Western blot, respectively. The subcellular locat...

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Literature Corpus work: 4d4240c1-7900-5876-9c7f-d779c0171328
DOI: 10.21203/rs.3.rs-1175463/v1

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