Article

ASTROGLIOSIS AND NEUROINFLAMMATION UNDERLIE SCOLIOSIS UPON CILIA DYSFUNCTION

2024-02-25

Abstract excerpt

<h4>ABSTRACT</h4> Cilia defects lead to scoliosis in zebrafish, but the underlying pathogenic mechanisms are poorly understood and may diverge depending on the mutated gene. Here, we dissected the mechanisms of scoliosis onset in a zebrafish mutant for the rpgrip1l gene encoding a ciliary transition zone protein. rpgrip1l mutant fish developed scoliosis with near-total penetrance but asynchronous onset in juven...

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Literature Corpus work: 53746d69-9d38-5ea7-86ad-4a776157efac
DOI: 10.1101/2024.02.22.581530

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