Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2C213Y mice.

doi:10.1016/j.nbd.2026.107572

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Article

Single-cell spatial transcriptomics reveals rewiring of RPE and Müller glia signaling toward photoreceptors following outer segment disruption in Prph2C213Y mice.

Neurobiology of disease - 1 Oct 2026

Guo Haoxin, Wei Linfei, Chen Binghan, Huang Juan, Zhu Meijiao, Li Xieyichang, Yan Ruiyi, Zhao Xufeng, Luo Minmin, Han Xiaoxu, Yu Weihong

Abstract excerpt

PRPH2 mutations cause inherited retinal dystrophies (IRDs), but how photoreceptor outer segment (OS) disruption reshapes the surrounding retina remains unclear. Using a heterozygous Prph2C213Y/+ mouse model generated by CRISPR/Cas9, we characterized age-related retinal pathology and responses of retinal pigment epithelium (RPE) and Müller glia. Independent age- and sex-matched cohorts were examined at 1, 3, and...

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Topics

Animals
Ependymoglial Cells
Mice
Retinal Pigment Epithelium
Spatial Transcriptomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Signal Transduction

Retinal Dystrophies

Retinal Photoreceptor Cell Outer Segment

Female

Transcriptome

Mice, Inbred C57BL

Mutation

Peripherins

Source

Open in PubMed

Identifiers

PMID: 42570777
DOI: 10.1016/j.nbd.2026.107572

Genes

RPE
PRPH2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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