Article

The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors

2024-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in CLRN1 cause Usher syndrome type IIIA (USH3A), an autosomal recessive disorder characterized by hearing and vision loss, and often accompanied by vestibular balance issues. The identity of the cell types responsible for the pathology and mechanisms leading to vision loss in USH3A remains elusive. To address this, we employed CRISPR/Cas9 technology to delete a large region in the cod...

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Literature Corpus work: c7b02724-11cc-5593-9515-af0224ea733d
DOI: 10.1101/2024.02.29.582878

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