Article

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of <i>PPP2R3B</i> causes idiopathic scoliosis

2018-09-10

Abstract excerpt

Idiopathic scoliosis (IS) is the deformation and/or abnormal curvature of the spine that develops progressively after birth. It is a very common condition, affecting approximately 4% of the general population, yet the genetic and mechanistic causes of IS are poorly understood. Here, we focus on PPP2R3B , which encodes a protein phosphatase 2A regulatory subunit that has been linked to regulation of autophagy. We...

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Literature Corpus work: 7d0c91f3-5405-538e-83ce-868891e95b3b
DOI: 10.1101/413526

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