Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis.

Scientific reports - 26 Apr 2023

Seda Marian, Crespo Berta, Corcelli Michelangelo, Osborn Daniel P, Jenkins Dagan

Abstract excerpt

Idiopathic scoliosis (IS) is the deformation and/or abnormal curvature of the spine that develops progressively after birth. It is a very common condition, affecting approximately 4% of the general population, yet the genetic and mechanistic causes of IS are poorly understood. Here, we focus on PPP2R3B, which encodes a protein phosphatase 2A regulatory subunit. We found that PPP2R3B is expressed at sites of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to CRISPR-Cas Systems
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Phosphatase 2

Share to Scoliosis

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 37100808
DOI: 10.1038/s41598-023-33589-y
PMCID: PMC10133272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosis.PMID 37100808Read ↗

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of PPP2R3B causes idiopathic scoliosisSemantic proximity Read ↗

A CRISPR/Cas9-generated mutation in the zebrafish orthologue of <i>PPP2R3B</i> causes idiopathic scoliosisSemantic proximity Read ↗

Understanding Idiopathic Scoliosis: A New Zebrafish School of Thought.Semantic proximity Read ↗

Ciliary and Osteogenic Defects as Central Drivers of AIS in POC5 Mutation Models.Semantic proximity Read ↗

Piezo1 Mutant Zebrafish as a Model of Idiopathic ScoliosisSemantic proximity Read ↗

The Application of Zebrafish Model in the Study of Idiopathic ScoliosisSemantic proximity Read ↗

Postembryonic screen for mutations affecting spine development in zebrafishSemantic proximity Read ↗

Mutations in KIF7 implicated in idiopathic scoliosis in humans and axial curvatures in zebrafish.Semantic proximity Read ↗

ptk7 mutant zebrafish models of congenital and idiopathic scoliosis implicate dysregulated Wnt signalling in disease.Semantic proximity Read ↗

An Update on Animal Models of Osteogenesis Imperfecta.Semantic proximity Read ↗

Ependymal polarity defects coupled with disorganized ciliary beating drive abnormal cerebrospinal fluid flow and spine curvature in zebrafishSemantic proximity Read ↗

Resolving primary pathomechanisms driving idiopathic-like spinal curvature using a new katnb1 scoliosis modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.