Article

Loss of the Reissner Fiber and increased URP neuropeptide signaling underlie scoliosis in a zebrafish ciliopathy mutant

2019-12-19

Abstract excerpt

<h4>SUMMARY</h4> Cilia-driven movements of the cerebrospinal fluid (CSF) are involved in zebrafish axis straightness, both in embryos and juveniles [1, 2]. In embryos, axis straightness requires cilia-dependent assembly of the Reissner fiber (RF), a SCO-spondin polymer running down the brain and spinal cord CSF-filled cavities [3]. Reduced expression levels of the urp1 and urp2 genes encoding neuropeptides of t...

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Literature Corpus work: 67564d49-7ba0-51e6-956d-f863b34cf2f8
DOI: 10.1101/2019.12.19.882258

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