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Regulation of FGF/MAPK signaling at the primary cilium base controls the proliferation-neurogenesis balance in human cerebellar organoids

2025-04-16

Abstract excerpt

<h4>ABSTRACT</h4> The primary cilium acts as a specialized signaling compartment that coordinates multiple developmental pathways, yet its role in regulating signaling activity during human brain development remains poorly understood. Biallelic mutations in ciliary genes cause neurodevelopmental ciliopathies such as Joubert syndrome, which are characterized by cerebellar hypoplasia and dysplasia. Here, we generat...

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Identifiers and source

Literature Corpus work
3f97ac3f-8cf2-5eea-845d-ecc58793f0a9
DOI
10.1101/2025.04.14.648790
Open publication

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Regulation of FGF/MAPK signaling at the primary cilium base controls the proliferation-neurogenesis balance in human cerebellar organoidsDOI 10.1101/2025.04.14.648790
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