Article

Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: a potential novel target in Parkinson’s disease.

2023-02-14

Abstract excerpt

<title>Abstract</title> <p>Dopaminergic degeneration is a central feature of Parkinson’s disease (PD), but glial dysfunction may accelerate or trigger neuronal death. In fact, astrocytes play a key role in maintenance of the blood-brain barrier and detoxification. 6-hydroxydopamine (6OHDA) is used to induce PD in rodent models due to its specific toxicity to dopaminergic neurons, but its effect on astrocytes has...

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Literature Corpus work: 5364e254-3fcf-5e97-9498-717f5039d8e1
DOI: 10.21203/rs.3.rs-2510273/v1

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