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Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?

18 Aug 2017

Abstract excerpt

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates hundreds of antioxidant genes, and is activated in response to oxidative stress. Given that many neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease and multiple sclerosis are characterised by oxidative stress, Nrf2 is commonly activated in...

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PMID: 28820437
DOI: 10.3390/antiox6030065

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