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Article

The Nrf2-mediated defense mechanism associated with HFE genotype limits vulnerability to oxidative stress-induced toxicity.

Toxicology - 1 Aug 2020

Song Insung Y, Snyder Amanda M, Kim Yunsung, Neely Elizabeth B, Wade Quinn W, Connor James R

Abstract excerpt

There is considerable interest in gene and environment interactions in neurodegenerative diseases. The HFE (homeostatic iron regulator) gene variant (H63D) is highly prevalent in the population and has been investigated as a disease modifier in multiple neurodegenerative diseases. We have developed a mouse model to interrogate the impact of this gene variant in a model of paraquat toxicity. Using primary...

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Identifiers

PMID: 32540480
DOI: 10.1016/j.tox.2020.152525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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