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Article

A Review on Notch Signaling and Colorectal Cancer.

Cells - 25 Jun 2020

Tyagi Ashish, Sharma Arun K, Damodaran Chendil

Abstract excerpt

Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway. The role of Notch receptors varies according to the difference in their structures; in particular, aberrant activation of Notch1 has been attributed to the severity of CRC....

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Identifiers

PMID: 32630477
DOI: 10.3390/cells9061549
PMCID: PMC7349609

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