Mutant TP53 Physically Sequesters FOXP3 to Abrogate PD-L1 Transcriptional Regulation and Drive Immune Evasion in Lung Adenocarcinoma: A Multi-Scale Computational Proof

Abstract excerpt

<title>Abstract</title> <p>Background Immune checkpoint therapy (ICT) targeting PD-1/PD-L1 fails in nearly half of lung adenocarcinoma (LUAD) patients. FOXP3, confirmed to be expressed tumor-cell-intrinsically in LUAD epithelium, directly regulates CD274 (PD-L1) transcription. I hypothesized that gain-of-function (GOF) mutant p53 (mutp53) physically sequesters FOXP3, preventing occupancy of its cognate CD274 pro...

Topics

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• CD4-Positive T-Lymphocytes
• GATA3 Transcription Factor
• Gene Expression Regulation, Neoplastic
• Lymphoma, T-Cell, Peripheral
• Mice
• Mutation
• PTEN Phosphohydrolase
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

535fe99a-e3a9-5fe0-aec7-942f0ac556ef

DOI

10.21203/rs.3.rs-9340414/v1