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Mutant TP53 differentially rewires FOXP3-mediated immune checkpoint regulation in a cancer lineage-dependent manner: a comprehensive pan-cancer computational analysis

2026-04-08

Abstract excerpt

<title>Abstract</title> <p>Background TP53 is the most frequently mutated gene in human malignancy, yet its role in rewiring tumor-intrinsic immune checkpoint signaling via transcription factor intermediaries remains poorly characterized. FOXP3, canonically the master regulator of regulatory T cells (Tregs), is increasingly documented in tumor epithelial cells where it may directly regulate immune checkpoint gen...

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Literature Corpus work
3533da1c-c5ff-5014-b363-bd16b456bf2c
DOI
10.21203/rs.3.rs-9342880/v1
Open publication

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Mutant TP53 differentially rewires FOXP3-mediated immune checkpoint regulation in a cancer lineage-dependent manner: a comprehensive pan-cancer computational analysisDOI 10.21203/rs.3.rs-9342880/v1
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