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Article

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.

Cell reports - 28 Jun 2012

Song Xiaomin, Li Bin, Xiao Yan, Chen Chunxia, Wang Qiang, Liu Yujie, Berezov Alan, Xu Chen, Gao Yayi, Li Zhiyuan, Wu Shiaw-Lin, Cai Zheng, Zhang Hongtao, Karger Barry L, Hancock Wayne W, Wells Andrew D, Zhou Zhaocai, Greene Mark I

Abstract excerpt

FOXP3 is a key transcription factor for regulatory T cell function. We report the crystal structure of the FOXP3 coiled-coil domain, through which a loose or transient dimeric association is formed and modulated, accounting for the activity variations introduced by disease-causing mutations or posttranslational modifications. Structure-guided mutagenesis revealed that FOXP3 coiled-coil-mediated homodimerization...

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Identifiers

PMID: 22813742
DOI: 10.1016/j.celrep.2012.04.012
PMCID: PMC3401381

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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