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Article

Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup.

Science advances - 17 Oct 2025

Lone Waseem G, Yu Jiayu, Liu Xuxiang, Jochum Dylan T, Bouska Alyssa, Shetty Kunal, Herek Tyler, Sharma Sunandini, Bi Chengfeng, Shah Rauf, Nasser Zaina W, Amador Catalina, Arif Aiza, Mir Abdul Rouf, Li Yuping, Heavican-Foral Tayla B, Robinson Jacob, Hyde R Katherine, Sakata-Yanagimoto Mamiko, Rachagani Satyanarayana, McKeithan Timothy W, Scott David W, Staudt Louis M, Inghirami Giorgio, Feldman Andrew, Greiner Timothy, Vose Julie M, Rimsza Lisa, Khoury Joesph, Chan Wing C, Iqbal Javeed

Abstract excerpt

Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL-not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (TH2)-like differentiation and poor prognosis, has frequent co-occurrence of TP53 loss/mutation and heterozygous PTEN loss. CD4+ T cell conditional mouse models with Trp53 mutation/deletion...

Read the complete abstract on PubMed

Topics

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Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GATA3 Transcription Factor

Share to Gene Expression Regulation, Neoplastic

Share to Lymphoma, T-Cell, Peripheral

Share to Mutation

Share to PTEN Phosphohydrolase

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41105775
DOI: 10.1126/sciadv.adx6877
PMCID: PMC12533597

Genes

GATA3
PTEN
TP53
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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