Germline whole-exome sequencing reveals FOXP3-related gene variants conferring urinary cancer susceptibility and associated with immune escape.

doi:10.1136/jitc-2024-010417

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Article

Germline whole-exome sequencing reveals FOXP3-related gene variants conferring urinary cancer susceptibility and associated with immune escape.

Journal for immunotherapy of cancer - 16 Sept 2025

Feng Bing-Jian, Kohlmann Wendy, Nix David A, Atkinson Aaron, Boucher Kenneth M, Carroll Courtney, Stubben Chris J, Kolesar Jill, Singer Eric A, Riedlinger Gregory, Edge Stephen, Sahu Kamal Kant, Churchman Michelle, Graham Laura, Salhia Bodour, Sanchez Alejandro, Zakharia Yousef, Schneider Bryan P, Jain Rohit, Byrne Lindsey, Moskaluk Christopher A, Nepple Kenneth, Shabsigh Ahmad, Chahoud Jad, Cairns Bradley R, Gupta Sumati

Abstract excerpt

BACKGROUND: The heritability of urinary tract cancer (UTC) remains unexplained by known pathogenic germline variants, and the influence of germline variants on treatment response to immune checkpoint inhibition (ICI) has yet to be fully elucidated. METHODS: In this case-control study, we performed a germline whole-exome sequencing of 810 UTC patients from the Oncology Research Information Exchange Network. A...

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PMID: 40962358
DOI: 10.1136/jitc-2024-010417
PMCID: PMC12443205

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FOXP3

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