Article

Lineage-Specific Rewiring of the JAK-STAT Signalling Axis by Mutant TP53 Drives Pan-Cancer Immune Evasion: A Comprehensive Analysis of 5,775 TCGA Samples

2026-05-19

Abstract excerpt

<title>Abstract</title> <p>Background Mutant TP53 (mutp53) is the most frequent oncogenic alteration in human cancer, yet its capacity to reshape tumour immunology across tissue lineages remains incompletely understood. I hypothesized that mutp53-driven rewiring of the JAK-STAT axis would exhibit lineage-specific patterns with distinct immune and clinical consequences. Methods Pan-cancer analysis integrating RN...

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Literature Corpus work: c3b4af08-8e4b-5288-9eab-d7b0aad86730
DOI: 10.21203/rs.3.rs-9737941/v1

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