Article

Embryonic requirements for <i>Tcf12</i> in the development of the mouse coronal suture

2021-03-02

Abstract excerpt

A major feature of Saethre-Chotzen syndrome is coronal craniosynostosis, the fusion of the frontal and parietal bones at the coronal suture. It is caused by heterozygous loss-of-function mutations in the basic HLH transcription factors TWIST1 and TCF12 . While compound heterozygous Tcf12; Twist1 mice display severe coronal synostosis, the individual role of Tcf12 has remained unexplored. Here we show that Tcf1...

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Literature Corpus work: d4f3295a-4669-5d59-be7f-df48773dcf92
DOI: 10.1101/2021.03.01.433456

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