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Article

How to form and close the brain: insight into the mechanism of cranial neural tube closure in mammals.

Cellular and molecular life sciences : CMLS - 1 Sept 2013

Yamaguchi Yoshifumi, Miura Masayuki

Abstract excerpt

The development of the embryonic brain critically depends on successfully completing cranial neural tube closure (NTC). Failure to properly close the neural tube results in significant and potentially lethal neural tube defects (NTDs). We believe these malformations are caused by disruptions in normal developmental programs such as those involved in neural plate morphogenesis and patterning, tissue fusion, and...

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Identifiers

PMID: 23242429
DOI: 10.1007/s00018-012-1227-7
PMCID: PMC3742426

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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