An Essential Requirement for Fgf10 in Pinna Extension Sheds Light on Auricle Defects in LADD Syndrome

Abstract excerpt

The pinna (or auricle) is part of the external ear, acting to capture and funnel sound toward the middle ear. The pinna is defective in a number of craniofacial syndromes, including Lacrimo-auriculo-dento-digital (LADD) syndrome, which is caused by mutations inFGF10or its receptorFGFR2b. Here we study pinna defects in theFgf10knockout mouse. We show that Fgf10 is expressed in both the muscles and forming...

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