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<i>Clostridioides difficile</i> toxin A and toxin B inhibit toxin-specific adaptive immune responses through glucosyltransferase-dependent activity

2025-08-02

Abstract excerpt

Clostridioides difficile colonizes the gastrointestinal tract and secretes two virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity against C. difficile infection is limited as patients are susceptible to multiple rounds of recurrent infections. The factors determining whether immunity to TcdA and TcdB is generated remain incompletely defined. We determined that C. difficile -infected mice g...

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Identifiers and source

Literature Corpus work
06208f58-a4fb-5c44-b5ef-24807095f100
DOI
10.1101/2025.07.30.667646
Open publication

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