Article

Binary toxin expression by <i>Clostridioides difficile</i> is associated with worse disease

2021-08-01

Abstract excerpt

<h4>Background</h4> The incidence of Clostridioides difficile infection (CDI) has increased over the past two decades and is considered an urgent threat by the Centers for Disease Control. Hypervirulent strains such as ribotype 027, that possess genes for an additional toxin C. difficile binary toxin (CDT) are contributing to increased morbidity and mortality. In the mouse model, CDT activates Toll-like receptor 2...

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Literature Corpus work: debe293f-4c93-5a82-855a-9426f8384ca4
DOI: 10.1101/2021.07.30.21261256

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