Article

Isofagomine inhibits multiple TcdB variants and protects mice from <i>Clostridioides difficile</i> induced mortality

2023-09-19

Abstract excerpt

Clostridioides difficile causes life-threatening diarrhea and is the leading cause of healthcare associated bacterial infections in the United States. During infection, C. difficile releases the gut-damaging toxins, TcdA and TcdB, the primary determinants of disease pathogenesis and are therefore therapeutic targets. TcdA and TcdB contain a glycosyltransferase domain that uses UDP-glucose to glycosylate host Rho...

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Literature Corpus work: b8e22687-b592-5ff1-b2f7-c483e087f156
DOI: 10.1101/2023.09.19.558375

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