Toxin B is essential for virulence of Clostridium difficile.

doi:10.1038/nature07822

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Article

Toxin B is essential for virulence of Clostridium difficile.

Nature - 30 Apr 2009

Lyras Dena, O'Connor Jennifer R, Howarth Pauline M, Sambol Susan P, Carter Glen P, Phumoonna Tongted, Poon Rachael, Adams Vicki, Vedantam Gayatri, Johnson Stuart, Gerding Dale N, Rood Julian I

Abstract excerpt

Clostridium difficile is the leading cause of infectious diarrhoea in hospitals worldwide, because of its virulence, spore-forming ability and persistence. C. difficile-associated diseases are induced by antibiotic treatment or disruption of the normal gastrointestinal flora. Recently, morbidity and mortality resulting from C. difficile-associated diseases have increased significantly due to changes in the...

Topics

Animals
Bacterial Adhesion
Bacterial Proteins
Bacterial Toxins
Cell Line
Clostridioides difficile
Cricetinae
Disease Models, Animal
Enterotoxins
Humans
Mutation
Virulence

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Identifiers

PMID: 19252482
DOI: 10.1038/nature07822
PMCID: PMC2679968

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