Article
Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities.
Infection and immunity - 11 Jan 2016
Quesada-Gómez Carlos, López-Ureña Diana, Chumbler Nicole, Kroh Heather K, Castro-Peña Carolina, Rodríguez César, Orozco-Aguilar Josué, González-Camacho Sara, Rucavado Alexandra, Guzmán-Verri Caterina, Lawley Trevor D, Lacy D Borden, Chaves-Olarte Esteban
Abstract excerpt
Clostridium difficile strains within the hypervirulent clade 2 are responsible for nosocomial outbreaks worldwide. The increased pathogenic potential of these strains has been attributed to several factors but is still poorly understood. During a C. difficile outbreak, a strain from this clade was found to induce a variant cytopathic effect (CPE), different from the canonical arborizing CPE. This strain (NAP1V)...
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