Article

A cleaved cytosolic FOXG1 promotes excitatory neurogenesis by enhancing mitochondrial translation

2024-08-13

Abstract excerpt

The modulation of mitochondrial function is core to cell fate decisions and tissue homeostasis, yet the mechanisms regulating these processes remain poorly understood. Here, we demonstrate that mitochondrial OXPHOS activity is controlled in a tissue-specific manner through a non-canonical cytoplasmic function of the transcription factor FOXG1. A temporally regulated short cytoplasmic FOXG1 interacts with mitochond...

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Literature Corpus work: 53455af3-6c1e-5faf-9a8e-420c58e58f5d
DOI: 10.1101/2024.08.13.607559

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