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Article

Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.

Nucleic acids research - 7 May 2021

Zhang Qinghai, He Xiao, Yao Shihao, Lin Tianxiang, Zhang Luwen, Chen Danni, Chen Chao, Yang Qingxian, Li Feng, Zhu Yi-Min, Guan Min-Xin

Abstract excerpt

Deficient maturations of mitochondrial transcripts are linked to clinical abnormalities but their pathophysiology remains elusive. Previous investigations showed that pathogenic variants in MTO1 for the biosynthesis of τm5U of tRNAGlu, tRNAGln, tRNALys, tRNATrp and tRNALeu(UUR) were associated with hypertrophic cardiomyopathy (HCM). Using mto1 knock-out(KO) zebrafish generated by CRISPR/Cas9 system, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Electron, Transmission

Share to Myocytes, Cardiac

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Share to RNA, Mitochondrial

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Identifiers

PMID: 33836087
DOI: 10.1093/nar/gkab228
PMCID: PMC8096277

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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