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Human patient-specific FOXG1 syndrome mouse model revealed FOXG1-MYCN-mediated regulation of protein homeostasis in neurodevelopmental disorder

2025-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Neurodevelopmental disorders are characterized by disruptions in brain development, resulting in cognitive, behavioral, and neurological impairments. FOXG1 syndrome (FS), caused by heterozygous mutations in the FOXG1 gene, exemplifies a severe monogenic neurodevelopmental disorder. To investigate its pathogenesis, we generated a patient-specific W300X mouse model carrying a truncation variant o...

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Literature Corpus work
1ed8fd4f-49cd-58e9-9b91-0f34e69a8382
DOI
10.1101/2025.09.27.678882
Open publication

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Human patient-specific FOXG1 syndrome mouse model revealed FOXG1-MYCN-mediated regulation of protein homeostasis in neurodevelopmental disorderDOI 10.1101/2025.09.27.678882
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