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Article

Nonsense-mediated mRNA decay in neuronal physiology and neurodegeneration

3 Aug 2023

Abstract excerpt

The processes of mRNA export from the nucleus and subsequent mRNA translation in the cytoplasm are of particular relevance in eukaryotic cells. In highly polarised cells such as neurons, finely-tuned molecular regulation of these processes serves to safeguard the spatiotemporal fidelity of gene expression. Nonsense-mediated mRNA decay (NMD) is a cytoplasmic translation-dependent quality control process that...

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PMID: 37543480
DOI: 10.1016/j.tins.2023.07.001

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