Article

AAV-mediated neuronal expression of FOXG1 restores oligodendrocyte maturation, myelination, and hippocampal structure in mouse models of FOXG1 syndrome

2025-12-05

Abstract excerpt

<h4>ABSTRACT</h4> FOXG1 syndrome is a devastating neurodevelopmental disorder caused by haploinsufficiency of the transcription factor FOXG1, leading to intellectual disability, epilepsy, and white-matter deficits. Although FOXG1 is well known for its neuronal functions, its role in glial pathology remains poorly understood. Here, we show that reducing FOXG1 selectively in neurons impairs oligodendrocyte lineage...

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Literature Corpus work: 0bbf1299-9147-5b59-bca1-f53fcfc4ac55
DOI: 10.64898/2025.12.04.692422

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