Article
Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets.
American journal of human genetics - 6 Apr 2023
Singhal Pankhuri, Veturi Yogasudha, Dudek Scott M, Lucas Anastasia, Frase Alex, van Steen Kristel, Schrodi Steven J, Fasel David, Weng Chunhua, Pendergrass Rion, Schaid Daniel J, Kullo Iftikhar J, Dikilitas Ozan, Sleiman Patrick M A, Hakonarson Hakon, Moore Jason H, Williams Scott M, Ritchie Marylyn D, Verma Shefali S
Abstract excerpt
Leveraging linkage disequilibrium (LD) patterns as representative of population substructure enables the discovery of additive association signals in genome-wide association studies (GWASs). Standard GWASs are well-powered to interrogate additive models; however, new approaches are required for invesigating other modes of inheritance such as dominance and epistasis. Epistasis, or non-additive interaction between...
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