A novel tumor-targeted interferon-alpha/-beta receptor 1 antagonist increases replication of oncolytic vesicular stomatitis virus in a mouse mesothelioma model

Abstract excerpt

Type I Interferons (IFN-I) are cytokines with pleiotropic activities involved in antiviral and antitumor immune responses. They can reduce oncolytic virus replication in tumor cells by inducing expression of interferon stimulated genes (ISG) with antiviral functions. To specifically neutralize the IFN-α/-β receptor (IFNAR) on specific cell types, we created novel IFNAR1-targeted antagonists constituted of a high-a...

Topics

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• Animal Disease Management and Epidemiology
• CAR-T cell therapy research
• Cytokine Signaling Pathways and Interactions
• Hepatitis C virus research
• interferon and immune responses
• T-cell and Retrovirus Studies
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

53314cd2-eab4-5e23-826a-43c4690a6ea3

DOI

10.64898/2026.06.02.729496