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Article

Investigations of Interferon-Lambda for the Treatment of Cancer

6 Feb 2015

Abstract excerpt

Interferon-lambda (IFN-λ), a recently discovered cytokine, overlaps broadly with type I IFN signaling, producing antiviral, antiproliferative, and proapoptotic responses. In comparison to type I IFNs, IFN-λ has a limited spectrum of responsive tissues due to variation in expression of the IFN-λ receptor IFNLR1. Type I IFNs have been investigated for their antitumor effects and used in the clinical setting for a...

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PMID: 25661266
DOI: 10.1159/000370113

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