Article

Reovirus sensitizes microsatellite stable colorectal cancer to anti-PD-1 treatment via cross-talk in innate and adaptive immune systems

2021-09-04

Abstract excerpt

<h4>Background</h4> Microsatellite stable (MSS) colorectal cancer (CRC) represents ~ 85% of all CRCs. These tumors are poorly immunogenic and largely resistant to immunotherapy, necessitating a need to develop new immune enhancing strategies. Oncolytic reovirus has a high propensity to replicate in KRAS mutant tumors which account for ~ 50% of MSS CRCs. Current study explores the ability of reovirus to potenti...

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Literature Corpus work: 26636ed0-f5c6-5b26-b1f3-1b3fa023dd00
DOI: 10.1101/2021.09.03.458915

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