Article

TNFRSF14 (HVEM) is a novel immune checkpoint for cancer immunotherapy in humanized mice

2019-07-23

Abstract excerpt

<h4>Background</h4> TNFRSF14 (herpes virus entry mediator (HVEM) delivers a negative signal to T cells through the B and T Lymphocyte Attenuator (BTLA) molecule and has been associated with a worse prognosis in numerous malignancies. A formal demonstration that the HVEM/BTLA axis can be targeted for cancer immunotherapy is however still lacking. <h4>Methods</h4> We used immunodeficient NOD.SCID.gc-null mice reco...

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Literature Corpus work: ea59e33f-93b0-5ac2-ba32-b244af75aa9c
DOI: 10.1101/711119

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