Article

Targeting cancer-intrinsic protein neddylation bypasses the loss of JAK/STAT signaling and overcomes acquired resistance to immunotherapy

2026-08-06

Abstract excerpt

<title>Abstract</title> The loss of IFNγ signaling in cancer cells causes primary and acquired resistance to immunotherapy. Using a patient-derived JAK2-deficient melanoma cell line, we have developed a co-culture system to model acquired resistance to immunotherapy. Genome-wide genetic screens uncover that protein neddylation can be targeted to restore sensitivity to PD1 blockade in co-cultures, and in MHC-I...

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Literature Corpus work: ec1bed62-b8e4-5846-b6f6-d63d4655b2d8
DOI: 10.21203/rs.3.rs-9107846/v1

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