Article

CRISPR/Cas9-mediated TGFβRII Disruption Enhances Anti-tumor Efficacy of Human Chimeric Antigen Receptor T Cells in Vitro

2021-08-23

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: CAR T-cell therapy has been recently unveiled as one of the most promising cancer therapies in hematological malignancies. However, solid tumors mount a profound line of defense to escape immunosurveillance by CAR T-cells. Among them, cytokines with an inhibitory impact on the immune system such as IL-10 and TGFβ are of great importance: TGFβ is a pleiotropic cy...

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Literature Corpus work: 9326b80b-0011-564f-9b82-3e439b098635
DOI: 10.21203/rs.3.rs-823875/v1

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